以二氧化钛负载磷钨钼杂多酸为催化剂,通过丁醛和1,2-丙二醇反应合成了丁醛1,2-丙二醇缩醛。系统考察了丁醛和1,2-丙二醇物质的量比、催化剂用量,以及反应时间诸因素对产品收率的影响。确定的适宜工艺条件为n(丁醛)∶n(1,2-丙二醇)=1∶1.7,催化剂用量为反应物料总质量的1.0%,带水剂环己烷8mL,反应时间1.0h。在此反应条件下,丁醛1,2-丙二醇缩醛的收率可达80.8%. The titanyl-supported phosphotungstomolybdic heteropolyacid was used as a catalyst to synthesize butanal 1,2-propanediol acetal by the reaction of butyraldehyde and 1,2-propanediol. The effects of the ratio of butylaldehyde to 1,2-propanediol, the amount of catalyst and the reaction time on the yield of the product were systematically investigated. The suitable process conditions were n (butyraldehyde): n (1,2-propanediol) = 1: 1.7, the amount of catalyst was 1.0% of the total mass of the reaction mass, cyclohexane 8mL, the reaction time 1.0h. Under this reaction condition, the yield of butyraldehyde 1,2-propanediol acetal reached 80.8%.