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目的 制作一种新型围产期缺氧缺血性脑损伤（HIBD）的动物模型，为进一步深入研究其病理生理机制及治疗方法提供条件。方法 结扎足月妊娠待产（妊娠19.5d）昆明母鼠双侧子宫动脉，不同时间行剖宫产娩出胎鼠,与正常剖宫产娩出的胎鼠相比较，观察实验胎鼠的生长发育及脑部病理改变。结果 随着结扎子宫动脉阻断血供时间的延长，胎鼠的死亡率迅速增高，两者具有直线正相关关系（P＜0.05），实验组胎鼠体重增长明显减慢，运动发育迟滞，脑部的病理改变与人类HIBD的改变相一致。结论 通过结扎孕鼠双侧子宫动脉，胎鼠所产生的一系列变化符合人类HIBD的改变，这是一种较理想的、操作较简便的复制HIBD动物模型的方法。
Objective To make a new animal model of perinatal hypoxic-ischemic brain damage (HIBD) and provide conditions for further study of its pathophysiological mechanism and treatment. Methods Ligation of full-term pregnancy to be born (19.5d) Kunming female rats bilateral uterine artery, cesarean delivery of fetal rats at different times, compared with normal cesarean delivery of fetal rats compared to observe the growth and development of experimental fetus and brain Department of pathology. Results With the prolongation of blood supply by uterine artery ligation, the mortality of fetal rats increased rapidly with a positive linear correlation (P <0.05). The weight gain of fetal rats decreased significantly, and the motor retardation and brain Department of pathological changes and changes in human HIBD consistent. Conclusions A series of changes in the bilateral uterine arteries and fetal mice that result from ligating pregnant rats are in line with the changes of human HIBD. This is an ideal and simple method for replicating animal models of HIBD.