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目的观察模拟失重对脑认知功能的影响及中药的干预效果。方法 16名志愿者,-6°头低位卧床(head-down bed rest,HDBR)3周前和卧床结束当天起床前各进行一次fMRI实验,包括中性、冲突两种任务模式和事件相关设计。随机分对照组(8人)、用药组(8人),用药组卧床期间服用自制中药制剂200 mL/d,3周,对照组服用等量安慰剂。结果两组模拟失重前:前扣带回、额叶和丘脑出现显著的激活。模拟失重后(对照组):额叶、前扣带回激活区的范围和信号强度较卧床前显著减少,丘脑激活消失。模拟失重后(用药组):前扣带回出现了显著的激活区,丘脑可见较显著的激活区,右侧额叶额中回小范围激活区。脑激活区范围和信号强度接近模拟失重前状态。结论模拟失重状态对认知功能有明显的影响,中药可以增强相关脑区对认知功能的调控作用。
Objective To observe the effect of simulated weightlessness on cognitive function of the brain and the effect of traditional Chinese medicine intervention. Methods Twenty-six volunteers, fMRI experiments were performed before bedtime at -6 ° head-down bed rest (HDBR) three weeks before and at the end of bed rest, including both neutral and conflict task patterns and event-related design. The patients in the control group were randomly divided into control group (8 persons) and medication group (8 persons). The medication group took self-made traditional Chinese medicine preparation 200 mL / d for 3 weeks while in bed, and the control group took the same amount of placebo. Results Before simulated weightlessness, both groups showed significant activation of anterior cingulate gyrus, frontal lobe and thalamus. After simulated weightlessness (control group), the area and signal intensity of the frontal lobe and the anterior cingulate gyrus returned to a significant reduction compared with those before bed rest, and the activation of the thalamus disappeared. After simulated weightlessness (medication group), there was a significant activation area in the anterior cingulate gyrus, a more significant activation area in the thalamus, and a smaller activation area in the right frontal gyrus. The extent of brain activation and signal intensity are close to those before simulated weightlessness. Conclusion Simulated weightlessness has a significant effect on cognitive function, and traditional Chinese medicine can enhance the regulation of cognition in relevant brain regions.