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目的探讨联合检测C反应蛋白(CRP)和动脉血氧分压(PaO2)分布变化作为重症急性胰腺炎(SAP)早期预测指标的可行性。方法按1996年全国统一诊断标准,将2004年1月~2005年12月收治的102例急性胰腺炎病人的临床资料进行回顾性分析,比较各组患者入院后第1、3、7、14天的CRP和PaO2含量。结果重症组CRP水平与轻症组CRP水平差异有统计学意义,且CRP水平与病情严重程度呈正相关。35例重症急性胰腺炎患者中有29例出现PaO2下降,死亡组与存活组PaO2比较差异有统计学意义(P<0.01)。结论CRP和PaO2含量变化与急性胰腺炎病情严重程度密切相关,是提示胰腺病变严重程度及可能发生重要器官功能损害的高危因素,可作为重症急性胰腺炎的早期预测指标。
Objective To investigate the feasibility of detecting the changes of C-reactive protein (CRP) and PaO2 distribution as early predictors of severe acute pancreatitis (SAP). Methods According to the national unified diagnostic criteria of 1996, the clinical data of 102 acute pancreatitis patients who were admitted from January 2004 to December 2005 were analyzed retrospectively. The patients in each group were compared on the 1st, 3rd, 7th and 14th days after admission Of CRP and PaO2 content. Results The CRP level in severe group was significantly different from that in mild group, and the CRP level was positively correlated with the severity of the disease. PaO2 decreased in 29 of 35 severe acute pancreatitis patients, and there was significant difference in PaO2 between death group and survival group (P <0.01). Conclusion The changes of CRP and PaO2 levels are closely related to the severity of acute pancreatitis and are risk factors for the severity of pancreatic lesions and the possible damage of vital organs. They may be used as early predictors of severe acute pancreatitis.