乳腺癌是一种生物学特征高度异质性的恶性肿瘤,全世界每年约41万女性死于乳腺癌[1]。在我国,乳腺癌发病呈上升趋势[2]。乳腺癌有多种生物学行为,临床病理特点和分子特征各不相同,其对治疗的反应和预后也明显不同。根据其组织学、免疫组化及分子生物学技术可将其分为不同的类型, Breast cancer is a highly heterogeneous malignancy of biological characteristics, with approximately 410,000 women worldwide dying each year from breast cancer [1]. In our country, the incidence of breast cancer is on the rise [2]. Breast cancer has a variety of biological behavior, clinical and pathological features and molecular characteristics vary, their response to treatment and prognosis are also significantly different. According to their histology, immunohistochemistry and molecular biology techniques can be divided into different types,