T4抗原或CD4分子是HIV的受体,HIV抗血清协同沉淀CD4。并非所有的抗CD4单克隆抗体(McAb)都能在体外阻断HIV感染,但一些CD4抗体如抗-leu3a和抗-OKT4a在高稀释度时(>1∶3000)能阻断HIV感染。抗-leu 3a诱生的抗独特型抗体(抗-Id)带有同HIV受体位点一致的内影像,它能模拟抗原(CD4),并能与HIV包膜糖蛋白结合。这种内影像抗-Id可能抑制HIV对靶细胞上的CD4结合,导致病毒灭活。 T4 antigen or CD4 molecules are HIV receptors, HIV antisera co-precipitated CD4. Not all anti-CD4 monoclonal antibodies block HIV infection in vitro, but some CD4 antibodies such as anti-leu3a and anti-OKT4a block HIV infection at high dilutions (> 1: 3000). The anti-leu 3a-induced anti-idiotypic antibody (anti-Id) carries an internal image consistent with the HIV receptor site, which mimics the antigen (CD4) and binds to the HIV envelope glycoprotein. This internal imaging of anti-Id may inhibit HIV binding to CD4 on target cells, leading to virus inactivation.