棉酚是从棉花作物中分离出来的一种淡黄色酚类化合物。中国首先发现食用粗制棉籽油可导致男性不育,且棉酚是其主要成分。临床上虽有过一些有关副作用的报道,但证明棉酚作为一种男性抗生育剂,其有效率达99.89%。为了阐明这种男性抗生育剂的作用机制,迄今曾在细胞及组织水平上研究了这些化合物的药理动力学和毒理学。然而,在 Gossypol is a light yellow phenolic compound isolated from cotton crops. China first discovered that consumption of crude cottonseed oil can lead to male infertility, and gossypol is the main component. Although there are some clinical reports of side effects, but proved that gossypol as a male anti-fertility agent, the effective rate of 99.89%. To elucidate the mechanism of action of this male anti-fertility agent, the pharmacokinetics and toxicology of these compounds have hitherto been studied at the cellular and tissue level. However, at