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利用遗传流行病学的理论与方法，对６４１个核心家系完整资料分析的结果表明，父母患哮喘是其子女患哮喘的重要因素，患哮喘的危险性比父母均不患哮喘家系的子女增加４．０～８．０倍，这种差别具有高度显著性意义。父母对子女患哮喘危险性的影响呈现显著的线性趋势（Ｐ＜０．０１）。显示了哮喘的发病具有家族聚集性。同时分析了父母患哮喘的儿子与女儿患哮喘危险性，没有发现两者间的显著性差别（Ｐ＞０．０５）。本研究没有发现父母的气道反应性与其子女的气道反应性有显著相关性。本文初步研究结果提示哮喘发病过程中，遗传因素起着重要的作用。
Using the theories and methods of genetic epidemiology, the complete data analysis of 641 nuclear families shows that parents suffer from asthma is an important factor in the children’s asthma, the risk of asthma than the parents of children without asthma pedigree increased by 4 .0 to 8.0 times, this difference has a highly significant significance. Parents’ risk of developing asthma in children showed a significant linear trend (P <0.01). The incidence of asthma is shown to be familially clustered. At the same time, we analyzed the risk of asthma in sons and daughters with parents of asthma, and found no significant difference (P> 0.05). This study found no significant correlation between parental airway responsiveness and their child’s airway responsiveness. The preliminary results of this study suggest that genetic factors play an important role in the pathogenesis of asthma.