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骨髓增生异常综合征(MDS)是克隆性造血干细胞疾病,其基本病理特征是无效造血,并表现为骨髓细胞病态造血和细胞表面标记的混杂表达。对MDS患者进行细胞免疫表型检测可以分析原始细胞群、粒细胞群和单核细胞群的表达异常,有助于MDS的诊断。由于对MDS细胞免疫表型分析是一个非常复杂的过程,规范与统一标准、使检测结果具有可比性和可信性是关键问题。
Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease whose basic pathological features are hematopoietic failure and is characterized by promiscuous expression of myeloid pathological hematopoiesis and cell surface markers. The detection of cellular phenotype in MDS patients can analyze the abnormal expression of primitive cell population, granulocyte population and monocyte population, which is helpful for the diagnosis of MDS. Because immunophenotyping of MDS cells is a very complex process, the standardization and harmonization of standards and the comparability and credibility of test results are the key issues.