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目的观察米非司酮治疗子宫内膜异位(EMS)的临床疗效。方法 38例确诊子宫内膜异位的患者,月经周期第2天起服用米非司酮,1次/d,12.5mg/次,3个月为1个疗程,1～2个疗程后比较治疗前后患者症状、体征、血清激素水平及不良反应情况。结果用药3个月后患者痛经等症状有所改善,有效率达93%。用药后子宫活动度改善,卵巢囊肿缩小,差异有统计学意义(P<0.05)。结论小剂量米非司酮治疗EMs疗效确切且安全,具有推广运用价值。
Objective To observe the clinical efficacy of mifepristone in the treatment of endometriosis (EMS). Methods Thirty-eight patients with endometriosis were treated with mifepristone on the second day of the menstrual cycle, once / d, 12.5mg / time, one course for three months and one to two courses after treatment Before and after the patient’s symptoms, signs, serum hormone levels and adverse reactions. Results 3 months after treatment, dysmenorrhea and other symptoms have improved, the effective rate of 93%. Uterine activity improved after treatment, ovarian cysts reduced, the difference was statistically significant (P <0.05). Conclusion Low-dose mifepristone is effective and safe in the treatment of EMs and has the value of popularization and application.