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前文曾报道了以六甲基二硅氨基锂(LHMDS)为碱合成标题化合物的方法。进一步的实验表明,以叔丁醇钾为碱用于芳香族α-碳基烯酮环二硫代缩醛类化合物的合成效果较好。为此,本文以叔丁醇钾为碱合成了1_(a—j)等10个标题化合物,其中1_(d—j)为新化合物。实验表明,碱的浓度、反应所用溶剂对产物的产率有明显影响。叔丁醇钾的浓度以0.4 mol/L左右为宜,采用苯和DMF混合溶剂并以脂环酮为底物时产率较好。
The previous article reported the synthesis of the title compound using lithium hexamethyldisilazide (LHMDS) as a base. Further experiments show that the use of potassium tert-butoxide as a base for the aromatic α-carboketene ketone ring dithioacetal compounds synthesized better. For this purpose, 10 title compounds such as 1-a-j were synthesized using potassium tert-butoxide as a base, among which 1-d-j was a new compound. Experiments show that the concentration of alkali, the solvent used in the reaction has a significant impact on the yield of the product. The concentration of potassium tert-butoxide is about 0.4 mol / L, and the yield is good when benzene and DMF mixed solvent is used and alicyclic ketone is the substrate.