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目的探讨血浆抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白(原)降解产物(FDP)、D-二聚体(D-D)联合检测在外科重症患者中的临床应用。方法 260例外科重症监护病房(SICU)的住院患者作为观察组,并选择同期健康体检人员50例作为健康对照组,分别检测两组人员的血浆AT-Ⅲ活性和FDP、D-D的含量,并进行统计分析。结果观察组血浆AT-Ⅲ活性明显低于健康对照组,差异有统计学意义(P<0.05);而血浆FDP、D-D含量明显高于健康对照组,差异有统计学意义(P<0.05)。结论 SICU患者存在血浆AT-Ⅲ、FDP、D-D水平异常,尽早检测及联合检测,对于SICU患者病情的早期诊断、判断病情及指导临床治疗具有较好的应用价值。
Objective To investigate the clinical application of combined detection of plasma antithrombin Ⅲ (AT-Ⅲ), fibrinogen (FDP) and D-dimer (D-D) in surgical critically ill patients. Methods In-hospital patients of 260 SICU patients were selected as the observation group, and 50 healthy subjects were selected as the healthy control group. The plasma AT-Ⅲ activity, FDP and DD contents in the two groups were measured and carried out Statistical Analysis. Results The plasma AT-Ⅲ activity in the observation group was significantly lower than that in the healthy control group (P <0.05). However, the content of plasma FDP and D-D in the observation group was significantly higher than that in the healthy control group (P <0.05). Conclusion There are abnormalities of plasma AT-Ⅲ, FDP and D-D in patients with SICU. Early detection and combined detection are of great value in the early diagnosis of SICU patients, judging the condition and guiding the clinical treatment.