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目的:探讨咖啡因在超低出生体重儿机械通气撤机过程中的作用,以缩短撤机时间,提高安全性,降低并发症。方法:选取2013年5月至2014年11月70例超低出生体重儿患者为研究对象,均予机械通气,在撤机观察中对照组予氨茶碱,观察组予咖啡因,观察在相关指标上变化情况。结果:疗效上,对照组显效率40%,总有效率85.71%;观察组显效率80%,总有效率100%,两组比较差异有统计学意义(P<0.05);并发症上,对照组并发症总发生率为20%,观察组并发症发生率为5.71%,两组比较差异有统计学意义(P<0.05);两组在心率、收缩压、中心静脉压、肺动脉压上比较差异无统计学意义(P>0.05);而在心排血量指数、尿量、呼吸频率、氧合指数、动脉血二氧化碳分压、p H值比较差异有统计学意义(P<0.05)。结论:咖啡因能降低超低出生体重儿机械通气撤机后并发症,安全性高。
Objective: To investigate the role of caffeine in the mechanical ventilation during weaning of ultra-low birth weight children in order to shorten the weaning time, improve safety and reduce complications. Methods: From May 2013 to November 2014, 70 patients with ultra-low birth weight were enrolled in this study. All patients were given mechanical ventilation. In the weaning control group, aminophylline was given to the control group and caffeine was observed in the observation group. Indicator changes. Results: In the treatment group, the effective rate of the control group was 40% and the total effective rate was 85.71%. The effective rate of the observation group was 80% and the total effective rate was 100%. There was significant difference between the two groups (P <0.05) The total complication rate was 20% in the observation group and 5.71% in the observation group, the difference between the two groups was statistically significant (P <0.05). The heart rate, systolic pressure, central venous pressure and pulmonary arterial pressure were compared There was no significant difference between the two groups (P> 0.05). There was significant difference in p H between cardiac output index, urine output, respiratory rate, oxygenation index and arterial partial pressure of carbon dioxide (P <0.05). Conclusion: Caffeine can reduce the complications of ultra-low birth weight children after mechanical ventilation and weaning, with high safety.