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目的:了解同期缩野加量治疗在鼻咽癌颈淋巴结治疗中的作用。材料与方法:从1995年12月至1997年2月将108例初治鼻咽癌病人采用分层随机的方法分为同期缩野加量治疗组(实验组)和常规治疗组(对照组),两组颈淋巴结阳性者各38例;实验组平均颈淋巴结大小为4684cm,对照组为4140cm,P>0.05;实验组平均颈部剂量为6867Gy,对照组为6642Gy,P>0.05。实验组平均颈部放疗天数为4534天,对照组为5247天,P<0.05。结果:放疗结束时,放疗后三个月,实验组颈淋巴结全消率分别为711%和974%,对照组分别为421%和605%,P<0.05。疗后3月颈淋巴结疗效的相关因素分析结果表明疗效与放疗剂量/天数比呈显著正相关。结论:同期缩野加量治疗能提高鼻咽癌颈淋巴结近期放疗疗效。时间剂量因子是放疗疗效的决定性因素之一。
OBJECTIVE: To understand the role of shrinking dosage during the same period in the treatment of cervical lymph node in nasopharyngeal carcinoma. Materials and Methods: From December 1995 to February 1997, 108 patients with newly diagnosed nasopharyngeal carcinoma were divided into two groups: control group (experimental group) and routine treatment group (control group) . The average cervical lymph node size was 4684 cm in the experimental group and 4140 cm in the control group, P> 0.05. The average cervical dose in the experimental group was 6867 Gy and that in the control group was 66 42Gy, P> 0.05. In the experimental group, the average number of days for cervical radiotherapy was 4534 days and that in the control group was 5247 days (P <0.05). Results: At the end of radiotherapy, the complete elimination rate of cervical lymph nodes was 711% and 974% in experimental group and 421% and 605% in control group respectively at three months after radiotherapy, P <0.05 . Results of analysis of related factors of cervical lymph node response after 3 months of treatment showed that there was a significant positive correlation between efficacy and dose / day ratio of radiotherapy. Conclusion: The same period of shrinkage plus dose treatment can improve the nasopharyngeal carcinoma neck lymph node short-term radiotherapy. Time dose factor is one of the decisive factors in the efficacy of radiotherapy.