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将当地雄性杂种犬随机分为手术组（ｎ＝９，施行ＢｉｌｒｏｔｈⅡ式胃切除术）和对照组（ｎ＝７，单纯剖腹术），两组犬手术后一个月始喂饲致癌剂甲基硝基亚硝基胍（ＭＮＮＧ）＋饱和氯化钠溶液，连续服用１０个月。在实验周期的不同时相点，应用纤维胃镜观察并活检胃粘膜，对ＭＮＮＧ＋饱和氯化钠溶液诱发犬残胃粘膜癌前病变过程中的组织病理学变化进行动态的观察研究。结果表明，残胃粘膜的病变首先是在遭受到物理和化学等因素损害的前提下发生、发展的。传统的Ｂｉｌｒｏｔｈ胃手术与残胃粘膜病变有直接的因果关系。手术组肠上皮化生和异型增生的发生率显著高于对照组（Ｐ＜０．０５～０．０１），吻合口部显著高于残胃部（Ｐ＜０．０５～０．０１），而对照组胃窦部与胃体部无显著差异（Ｐ＞０．０５）。因此，残胃是应引起高度重视的胃癌癌前状态。
The local male mongrel dogs were randomly divided into the surgical group (n=9, performing a Bilroth II gastrectomy) and the control group (n=7, a simple laparotomy). The dogs of the two groups were given a carcinogen methyletabe for one month after the operation. Chitosan (MNNG) + saturated sodium chloride solution, taking 10 consecutive months. At different time points of the experimental period, the gastric mucosa was observed and biopsied by fiberoptic gastroscopy. The histopathological changes during pretreatment of remnant gastric precancerous lesions in dog can be observed dynamically by MNNG+saturated sodium chloride solution. The results showed that the lesions of the remnant gastric mucosa first occurred and developed on the premise of physical and chemical damage. Traditional Bilroth gastric surgery has a direct causal relationship with residual gastric mucosal lesions. The incidence of intestinal metaplasia and dysplasia was significantly higher in the operation group than in the control group (P<0.05-0.01), and the anastomosis was significantly higher in the anastomosis than in the residual stomach (P<0.05-0.01). There was no significant difference between the gastric antrum and gastric body in the control group (P>0.05). Therefore, residual stomach is a precancerous condition of gastric cancer that should be given high priority.