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目的探讨干扰素联合丙种球蛋白治疗传染性单核细胞增多症(IM)患儿的临床疗效。方法选取2014年3月至2016年3月于深圳市罗湖区人民医院儿科治疗的80例IM患儿作为研究对象,按随机数字表法分为观察组与对照组,各40例。对照组患儿采用干扰素进行治疗,观察组采用干扰素联合丙种球蛋白治疗方案,比较两组患儿治疗效果、症状改善时间、实验室指标改善情况及T淋巴细胞亚群变化。结果观察组患儿治疗有效率为92.5%,显著高于对照组的77.5%,差异有统计学意义(P<0.05);观察组患儿退热时间、咽颊炎消退时间、淋巴结缩小时间、肝脾缩小时间均明显短于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患儿白细胞总数、谷氨酸转氨酶(ALT)及肌酸激酶同工酶(CK-MB)均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后观察组患者CD3~+CD4~+、CD3~+CD4~+/CD3~+CD8~+均显著高于对照组,CD3~+CD8~+明显低于对照组,差异均有统计学意义(均P<0.05)。结论干扰素联合丙种球蛋白治疗儿童IM疗效显著,症状改善快,可增强机体细胞免疫功能,具有积极临床意义。
Objective To investigate the clinical efficacy of interferon combined with gamma globulin in the treatment of children with infectious mononucleosis (IM). Methods From March 2014 to March 2016, 80 cases of IM pediatric patients with pediatric treatment in Luohu District People’s Hospital of Shenzhen City were selected as the research objects, divided into observation group and control group according to the random number table method, each 40 cases. The control group was treated with interferon. The observation group was treated with interferon plus gamma globulin. The therapeutic effect, the improvement of symptoms, the improvement of laboratory indexes and the changes of T lymphocyte subsets were compared between the two groups. Results The effective rate of treatment in observation group was 92.5%, which was significantly higher than that in control group (77.5%) (P <0.05). The observation group had better results in the treatment of fever, swallowed pharynx, lymph node reduction, After treatment, the total number of white blood cells, glutamic acid aminotransferase (ALT) and creatine kinase (CK) in the observation group were significantly lower than those in the control group (all P <0.05) -MB) were significantly lower than those in the control group (all P <0.05). After treatment, the levels of CD3 + CD4 +, CD3 + CD4 + / CD3 + CD8 + in the observation group were significantly higher than those in the control group Higher than the control group, CD3 ~ + CD8 ~ + was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Interferon gamma globulin in children with IM treatment of significant effect, rapid improvement of symptoms, can enhance cellular immune function, with a positive clinical significance.