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目的探讨新疆地区维汉妇女宫颈疾病及其癌变组织中Pokmon蛋白与P14ARF蛋白的表达及意义。方法采用免疫组化SP法检测240例新疆地区维汉族妇女宫颈病变中Pokmon蛋白和P14ARF蛋白的表达。维汉妇女各120例,依据病理诊断结果分为4组,非瘤变组(正常及慢性炎症组)30例、CINⅠ组30例、CINⅡ—Ⅲ组30例、宫颈鳞癌组30例。结果宫颈病变组织中Pokemon与P14ARF蛋白在维汉族之间的表达差异无显著性(P>0.05);随着宫颈病变程度的加重,不同组别之间Pokemon与P14ARF蛋白的表达有显著差异(P<0.05)。结论 Pokemon蛋白与P14ARF蛋白表达与宫颈疾病及其癌变的发生密切相关,呈正相关,Pokemon蛋白与P14ARF蛋白在新疆地区维汉妇女宫颈病变及其癌变中表达不存在民族差异。
Objective To investigate the expression and significance of Pokmon and P14ARF proteins in cervical cancer and its cancerous tissues in Uygur and Han women in Xinjiang. Methods Immunohistochemical SP method was used to detect the expression of Pokmon protein and P14ARF protein in 240 cases of Uygur women with cervical lesions in Xinjiang Uygur Autonomous Region. According to the results of pathological diagnosis, 120 cases were divided into 4 groups, 30 cases in non-neoplastic group (normal and chronic inflammatory group), 30 cases in CINⅠ group, 30 cases in CINⅡ-Ⅲ group and 30 cases in cervical squamous cell carcinoma group. Results There was no significant difference in the expression of Pokemon and P14ARF between Uygur and Han population in cervical lesions (P> 0.05). The expression of Pokemon and P14ARF in different groups were significantly different with the severity of cervical lesions (P <0.05). Conclusions There is a positive correlation between Pokemon protein and P14ARF protein expression and cervical cancer and its carcinogenesis. There is no national difference between Pokemon protein and P14ARF protein expression in cervical lesions and carcinogenesis of Uygur women in Xinjiang region.