论文部分内容阅读
目的：测定正常成人的肺弥散能力（ＤＬ）、肺泡毛细血管膜弥散能力（Ｄｍ）及肺毛细血管床容量（Ｖｃ），计算与年龄、身高、体重相关的回归方程；研究年龄对于ＤＬ特别是对Ｄｍ、Ｖｃ的影响以及后三者之间的关系。方法：单次呼吸法测定ＤＬＣＯ，测定不同吸入气氧分压下的ＤＬＣＯ，采用Ｒｏｕｇｈｔｏｎ和Ｆｏｓｔｅｒ方法计算Ｄｍ和Ｖｃ。结果：年龄与ＤＬ、Ｄｍ、Ｖｃ呈中度或高度负相关，ＤＬ与Ｄｍ和Ｖｃ、ＶＡ与ＤＬ、Ｄｍ和Ｖｃ中度或高度正相关；ＤＬ、Ｄｍ在４０岁以后开始降低，Ｖｃ在５０岁以后开始降低；在各年龄组ＤＬ、Ｄｍ和Ｖｃ的回归方程中，身高和／或年龄为进入公式的主要变量。结论：（１）年龄与Ｄｍ、Ｖｃ呈线性负相关；（２）Ｄｍ在４０岁以后开始降低，Ｖｃ减少发生在５０岁以后；（３）ＤＬ在４０岁以后随年龄增加而减少主要是由于Ｄｍ、Ｖｃ的降低所引起；（４）Ｄｍ、Ｖｃ的减少与ＶＡ随年龄变化有关；（５）身高和／或年龄是Ｄｍ、Ｖｃ回归方程的主要变量
OBJECTIVE: To determine the lung dispersibility (DL), alveolar capillary membrane diffusivity (Dm), and pulmonary capillary bed volume (Vc) in normal adults and to calculate regression equations related to age, height and weight. The impact on Dm, Vc and the relationship between the latter three. Methods: Single breath method was used to determine DLCO, DLCO was measured under different partial pressure of oxygen inhalation, and Roughton and Foster methods were used to calculate Dm and Vc. Results: There was a moderate or highly negative correlation between age and DL, Dm and Vc. There was a positive or moderate positive correlation between DL and Dm and Vc, VA and DL, Dm and Vc. DL and Dm began to decrease after age 40 and Vc was 50 The age began to decrease; in the age groups DL, Dm and Vc regression equation, height and / or age as the main variables into the formula. Conclusion: (1) There is a linear inverse relationship between age and Dm, Vc; (2) Dm begins to decrease after 40 years of age and Vc decreases after 50 years of age; (3) The decrease of DL with age after 40 years of age is mainly due to Dm and Vc; (4) The decrease of Dm and Vc is related to the change of VA with age; (5) The height and / or age are the main variables of Dm and Vc regression equation