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脊髓灰质炎口服疫苗和球蛋白缓和的麻疹减毒疫苗的分别使用,其有效率约在90%以上.但当两种病毒疫苗联合应用时,是否病毒间会产生干扰?是否球蛋白能抑制脊髓灰质炎病毒的免疫性?因此,对这两种病毒疫苗的联合应用进行免疫效果的评价是必需的. 作者选择了未服过脊髓灰质炎疫苗,亦没有麻疹病史的9个月到6岁的儿童,每个儿童口服三滴单价Ⅰ型或Ⅱ型脊髓灰质炎疫苗(200000-500000TCID_(50)),有15个儿童口服Ⅰ型疫苗,8个服Ⅱ型疫苗.这23个儿童也接受皮下注射减毒麻疹疫苗0.5毫升(1000TCID_(50)),同时在对侧三角肌区注入0.01毫升/磅体重人的免疫血清球蛋白.每个儿童在接种前采血标本.服Ⅰ型疫苗者在服后21～23天,服Ⅱ型疫苗者在服后16和44天,分别采血送检.脊髓灰质炎的抗体水平是以中和试验(变色法)确定的;麻疹的补体结合抗体和血凝抑制抗体也分别予以测定.接种前后的血清是同时测定的. 在口服Ⅰ型或Ⅱ型脊髓灰质炎疫苗的23个儿童
Polio oral vaccine and globulin ease the use of attenuated measles vaccine separately, the effective rate of about 90% or more.But when the two virus vaccine combination, whether the virus will interfere with? Whether globulin can inhibit the spinal cord Therefore, the combined use of the two vaccines for the evaluation of the immune effect is necessary.The authors chose not to have been polio vaccine, there is no history of measles 9 months to 6 years of age Children, three oral doses of either type I or type II polio vaccine (200 000-500 000 TCID 50) per child, 15 children oral administration of type I vaccine and 8 type II vaccines. The 23 children also received subcutaneous Inject 0.5 ml of attenuated measles vaccine (1000 TCID 50) into the contralateral deltoid area while injecting 0.01 ml per pound of human immunoglobulin, each child taking a blood sample prior to vaccination. After 21 to 23 days, those who took Type II vaccine were given blood samples at 16 and 44 days after their administration, respectively.The levels of antibodies to poliomyelitis were determined by the neutralization test (discoloration method); the complement of measles antibody and hemagglutination Inhibitory antibodies were also measured separately Before and after the serum was measured at the same time.In oral administration of type I or type II polio vaccine, 23 children