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目的观察甘利欣在肝动脉栓塞化疗时的保肝作用。方法 2 0例原发性肝癌患者在肝动脉栓塞化疗当天给予甘利欣保肝 ,并设 18例为对照。结果治疗组治疗前后肝功能无变化 ,对照组胆红素 (BIL ) 3天升高 ,2周末降至正常 ,丙氨酸转氨酶 (ALT)和天冬氨酸转氨酶 (AST) 3天、7天明显升高 ,2周降至正常 ,白蛋白 (Alb) 7天开始下降 ,2周回升 ,但未降至正常水平。结论甘利欣可防止正常肝细胞损害 ,保护肝功能 ,增强对栓塞化疗的耐受性
Objective To observe the effect of Glycyrrhizin on hepatoprotective effect during hepatic arterial chemoembolization. Methods Twenty patients with primary hepatocellular carcinoma were given Gan Lixin liver protection on the day of hepatic arterial chemoembolization and 18 as control. Results The liver function of the treatment group did not change before and after treatment. The level of bilirubin (BIL) in the control group increased 3 days, decreased to normal level 2 weeks later, the levels of ALT and AST were increased for 3 days and 7 days Significantly increased and decreased to normal after 2 weeks. Alb began to decline at 7 days and rebounded at 2 weeks but did not decrease to normal level. Conclusion Glycyrrhizin can prevent normal liver cell damage, protect liver function and enhance the tolerance to chemoembolization