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目的探讨二甲双胍提高糖尿病患者的血糖达标率,减少胰岛素用量,改善胰岛素抵抗。方法将60例糖尿病随即分为两组,二甲双胍联合胰岛素治疗组(A组)和胰岛素(B组)各30例,对照两种方法治疗糖尿病达到达标血糖的时间、胰岛素用量、体重变化进行比较。结果两种治疗方法最终均能达到相同的达标血糖值,但达到达标血糖值所需时间、胰岛素用量、体重变化均有差异。差异有统计学意义。结论二甲双胍联合胰岛素治疗糖尿病使得到稳定控制、改善胰岛素抵抗。
Objective To investigate the effect of metformin on glycemic control in diabetic patients, decrease insulin dosage and improve insulin resistance. Methods Sixty diabetic patients were randomly divided into two groups: metformin combined with insulin (group A) and insulin (group B) with 30 cases each. The control time, insulin dosage and body weight of two methods were compared. Results Both treatments eventually reached the same standard blood glucose level, but the time required to reach the standard blood glucose level, insulin dosage, and body weight changes varied. The difference was statistically significant. Conclusion Metformin in combination with insulin in the treatment of diabetes leads to stable control and improvement of insulin resistance.