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目的 研究晚期血吸虫病患者血清粒细胞集落刺激因子 (G- CSF)和转化生长因子 β1(TGF- β1 )水平的改变和临床意义。方法 采用酶联免疫吸附试验 (EL ISA)检测 30例晚期血吸虫病患者 (晚血组 )和 11例急性血吸虫病患者 (急血组 )血清 G- CSF和 TGF- β1 水平 ,并与 10例正常人(正常对照组 )作对照。结果 晚血组和急血组血清 G- CSF水平显著高于正常对照组 (P<0 .0 1,P<0 .0 5 ) ;急血组血清 TGF- β1 水平显著高于正常对照组 (P<0 .0 1) ,而晚血组升高不明显 (P>0 .0 5 ) ;急血组 G- CSF与 TGF- β1 水平之间呈显著正相关 (r=0 .7118,P<0 .0 5 ) ,晚血组则无显著相关 (r=0 .1982 ,P>0 .0 5 )。结论 血清 G- CSF能反映晚血患者合并感染 ,而血清 TGF- β1 不能反映晚血肝纤维化程度
Objective To study the changes and clinical significance of serum granulocyte colony stimulating factor (G-CSF) and transforming growth factor β1 (TGF-β1) in patients with advanced schistosomiasis. Methods Serum levels of G-CSF and TGF-β1 in 30 patients with advanced schistosomiasis (late blood group) and 11 patients with acute schistosomiasis (acute blood group) were detected by enzyme-linked immunosorbent assay (ELISA) People (normal control group) as a control. Results Serum levels of G-CSF in late blood group and acute blood group were significantly higher than those in normal control group (P <0.01, P <0.05). Serum levels of TGF-β1 in acute blood group were significantly higher than those in normal control group P <0.01), but no significant increase in late blood group (P> 0.05). There was a significant positive correlation between G-CSF and TGF-β1 in acute blood group (r = 0.71 18, P <0.05), there was no significant correlation between late blood group (r = 0.1982, P> 0.05). Conclusion Serum G-CSF can reflect the co-infection of patients with late blood, while serum TGF-β1 can not reflect the degree of late-onset liver fibrosis