论文部分内容阅读
为进一步提高疗效，减少毒副作用，我们对常规的COP、CHOP方案的用药剂量和时间均作了调整，并就阿霉素使用的安全剂量及中毒后的救治提出我们的看法。我们认为两周内给予阿霉素80mg是一比较安全的剂量，过量的阿霉素可引起粒细胞缺乏症，生白能（人重组粒细胞-巨噬细胞集落刺激因子，GM-CSF）对粒细胞缺乏症的救治具有明确的疗效，通常在用药4天后白细胞总数开始回升，10天后基本上能渡过粒细胞缺乏期。
In order to further improve the curative effect and reduce toxic and side effects, we adjusted the dosage and time of conventional COP and CHOP regimens, and put forward our views on the safe dose of doxorubicin and the treatment after poisoning. We believe that giving 80 mg of doxorubicin within two weeks is a safer dose. Excess doxorubicin can cause agranulocytosis, and white canine (human recombinant granulocyte-macrophage colony-stimulating factor, GM-CSF) The treatment of agranulocytosis has a definite curative effect. Usually, the total number of white blood cells starts to rise after 4 days of administration, and after 10 days, the period of granulocyte depletion can be substantially overcome.