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由于心肌供氧与需氧的不平衡,造成心肌缺氧而导致心绞痛发作。目前较好的治疗措施是增加冠脉血流或降低心肌耗氧量。因此,了解心肌耗氧量的测定和估计方法,对于筛选有效的抗冠心病药物,进行药理研究和评价药物临床治疗效果,是很有意义的。 一、直接测定在体心肌耗氧量方法 测定在体心脏的耗氧量(简写为MVO_2)是基于Fick原理。Fick原理认为:心排出量等于人体氧摄取量(O_2ml/min)除以肺静脉与肺动脉的血氧差值。用公式表示:Q=VO_2/Cao_2-Cvo_2(VO_2=每分钟全
Due to myocardial oxygen supply and aerobic imbalance, resulting in myocardial ischemia caused angina attacks. The current better treatment is to increase coronary blood flow or reduce myocardial oxygen consumption. Therefore, to understand myocardial oxygen consumption measurement and estimation methods for the screening of effective anti-coronary drug drugs, pharmacological studies and evaluation of the clinical efficacy of drugs, is of great significance. First, the direct determination of myocardial oxygen consumption in vivo Determination of oxygen consumption in the body’s heart (abbreviated as MVO_2) is based on the Fick principle. Fick principle that: cardiac output is equal to the human body oxygen uptake (O_2ml / min) divided by the pulmonary vein and pulmonary arterial oxygen difference. With the formula: Q = VO_2 / Cao_2-Cvo_2 (VO_2 = full per minute