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目的寻找筛查大肠癌早期肝转移病人血清特异性蛋白。方法对中国人民解放军第202医院2007-2009年收治的20例大肠癌和20例大肠癌早期肝转移病人,应用表面增强激光解吸电离飞行时间质谱(SELDI-TOF-MS)技术检测其血清中特异性蛋白的相对含量。结果两组样本质荷比在2000～30000u间有3774u、11851u的2个蛋白峰有显著差异。结论 SELDI-TOF-MS技术对大肠癌早期肝转移的诊断和特异性肿瘤标记物的筛选等方面具有一定价值,值得推广。
Objective To search for serum specific proteins in patients with early liver metastases from colorectal cancer. Methods 20 cases of colorectal cancer and 20 cases of early colorectal cancer treated by the People’s Liberation Army No. 202 Hospital from 2007 to 2009 were tested for their serum specificity by surface enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The relative content of sex protein. Results There were significant differences in the two protein peaks of 3774u and 11851u between 2000 and 30000u in the two groups. Conclusion SELDI-TOF-MS technique has certain value in the diagnosis of early liver metastasis of colorectal cancer and the screening of specific tumor markers, and is worthy of promotion.