Comprehensive investigations along the Gyirong-Lugu-Sangehu geophysical profile in the western Xizang Plateau are presented. Analysis and interpretation of the lithospheric structure resulted in setting up of the geophysical methods and marks for the division of tectonic units in the lithospheric structure. Comprehensive geophysical survey in the remote west of Xizang is reported and some reliable geophysical evidence for deep structure division in the study region is provided. These lay a solid basis for probing into the mechanism of the Xizang Plateau uplift and geodynamics. Comprehensive investigations along the Gyirong-Lugu-Sangehu geophysical profile in the western Xizang Plateau are presented. Analysis and interpretation of the lithospheric structure resulted in setting up of the geophysical methods and marks for the division of tectonic units in the lithospheric structure. Comprehensive geophysical survey in the remote west of Xizang is reported and some reliable geophysical evidence for deep structure division in the study region is provided. These lay a solid basis for probing into the mechanism of the Xizang Plateau uplift and geodynamics.