目的了解消化性溃疡患儿胃ｐＨ值的动态变化。方法对２５例经胃镜确诊的消化性溃疡患儿作２４小时胃ｐＨ值测定，２５例健康儿作对照组。结果胃溃疡和十二指肠溃疡患儿各项胃ｐＨ值监测指标的差异无显著意义（Ｐ＞０．０５）；溃疡组胃ｐＨ平均值、平均中位数低于对照组（１．８±０．５比２．３±０．６，１．４±０．４比１．７±０．５，Ｐ分别＜０．０１、＜０．０５），而胃ｐＨ值＜２和＜３的时间百分比则高于对照组（７４．８±１３．７比６２．８±１５２，８５．９±８．６比７４．２±１３．１，Ｐ均＜０．０１）；溃疡组夜间胃ｐＨ平均值、平均中位数低于白天（１．６±０．５比２．１±０．５，１．３±０．４比１．６±０．５，Ｐ＜０．０１），而夜间胃ｐＨ值＜２和＜３的时间百分比则高于白天（８３．２±１４．０比６６．２±１９．９，９２．１±８．１比７９．７±１２．７，Ｐ均＜０．０１）。结论小儿消化性溃疡时胃酸分泌增多，夜间胃酸分泌明显多于白天，提示抑制夜间胃酸分泌是治疗小儿消化性溃疡的重要环节 Objective To understand the dynamic changes of gastric pH in children with peptic ulcer. Methods Twenty-five children with peptic ulcer diagnosed by endoscopy were enrolled in this study. The 24-hour stomach pH was measured and 25 healthy children served as the control group. Results There was no significant difference in gastric pH value between children with gastric ulcer and duodenal ulcer (P> 0.05). The average value of gastric pH in gastric ulcer group was lower than that of control group ± 0.5 vs. 2.3 ± 0.6, 1.4 ± 0.4 vs. 1.7 ± 0.5, P <0.01, <0.05, respectively) whereas gastric pH <2 and < 3 was higher than the control group (74.8 ± 13.7 vs 62.8 ± 152, 85.9 ± 8.6 vs 74.2 ± 13.1, P <0.01 respectively); Night gastric gastric ulcer average, mean median was lower than during daytime (1.6 ± 0.5 vs 2.1 ± 0.5, 1.3 ± 0.4 vs 1.6 ± 0.5, P < 0.01), while the percentages of nocturnal gastric pH values ​​<2 and <3 were higher than those during daytime (83.2 ± 14.0 vs 66.2 ± 19.9, 92.1 ± 8.1 vs 79.7 ± 12.7, P <0.01). Conclusion Gastric acid secretion in children with peptic ulcer increased, gastric acid secretion during night significantly more than during the day, suggesting that inhibition of nocturnal gastric acid secretion is an important part of the treatment of children with peptic ulcer