造成两个基因部分融合一起形成一个混合基因的突变,在血癌中比较常见,如今却在肺癌中发现了一个新的融合基因。据2007年8月2日的Nature杂志报导,索德(Soda)等发现染色体2P位点上基因的重排突变,激活为酪氨酸激酶编码的基因(ALK)。已知该酶是以加磷酸基到酪氨酸残基上的方式,调 The mutation that caused the two genes to fuse together to form a mixed gene, which is more common in blood cancers, now finds a new fusion gene in lung cancer. According to Nature, August 2, 2007, Soda et al. Found that a rearranged mutation in the 2P site of the chromosome was activated by a tyrosine kinase-encoding gene (ALK). It is known that this enzyme is based on the addition of phosphate to tyrosine residues