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众所周知,长QT综合征及Brugada综合征可增加猝死风险。JAMA上发表的一项最新前瞻性队列研究显示,与上述两种疾病相关的基因变异患病率与室性心律失常的发生及传导缺陷证据并无明显相关性。这提示以基因为基础的疾病预测存在一定的缺陷。研究者美国范德比尔特大学医学中心的Dan Roden及其同事入选2022例受试者,对包括SCN5A及KCNH2在内的、编码离子通道参与药物相互作用及药物反应的、携带与长
As we all know, long QT syndrome and Brugada syndrome can increase the risk of sudden death. A recent prospective cohort study published in JAMA showed no association between the prevalence of gene variants associated with these two diseases and evidence of ventricular arrhythmias and conduction defects. This suggests that genetic-based disease prediction has some drawbacks. Researchers Dan Roden and colleagues at the Vanderbilt University Medical Center at the United States enrolled 2,022 participants in a study involving ion channels involved in drug interactions and interactions involving SCN5A and KCNH2,