以健康豚鼠为对照,用脉冲火花发生器给动物不同强度爆震。震前、后测定脑干诱发电位,处死动物行耳蜗毛细胞内Na~+-K~+-ATP酶和DNA、RNA吖啶橙荧光组织化学染色。结果是,不同强度爆震造成不同程度损伤。毛细胞内Na~+-K~+-ATP酶活性与阈移两者间有一定的内在联系,酶活性降低很可能是听力阈移的重要原因之一。但是毛细胞内DNA、RNA荧光组化未见差异,表明爆震对耳蜗毛细胞内核酸影响可能不大,因此,耳科临床治疗爆震性耳聋,应十分注意内耳能量代谢。 Healthy guinea pigs as a control, the pulse spark generator to different intensities of knocking. Brainstem evoked potentials were measured before and after the earthquake, and Na ~ + -K ~ + -ATPase, DNA and RNA acridine orange fluorescence staining were performed in the cochlear cells of the animals. As a result, knocking at different intensities causes varying degrees of damage. There is a certain relationship between Na ~ + -K ~ + -ATPase activity and threshold shift in hair cells. Decreased enzyme activity is probably one of the important reasons for hearing threshold shift. However, there was no difference in fluorescence and DNA in hair cells, indicating that knocking may not affect the nucleic acid in cochlear hair cells. Therefore, deafness should be paid attention to.