一、β-内酰胺酶合成的基因控制很多革蓝氏阳性需氧菌产生染色体介导β-内酰胺酶。一些常见的微生物,特别是大肠杆菌和奇异变形菌的多数菌株只产生少量的β-内酰胺酶。很多菌种如阴沟肠杆菌、弗氏柠檬酸细菌和绿脓杆菌在合适的β-内酰胺类药物的存在下能诱导产生大量的酶,但是在不存在这类药物的情况下,只产生少量“基础”的β-内酰胺酶。由于遗传学研究最常用的革蓝氏阴性菌和临床上最常用的材料是不能诱导β-内酰胺酶的大肠杆菌,所以对诱导性β-内酰胺酶合 First, the β-lactamase gene synthesis control Many blue-positive aerobic bacteria produce chromosome-mediated β-lactamase. Most strains of common microorganisms, especially Escherichia coli and Proteus mirabilis, produce only small amounts of beta-lactamase. Many species of bacteria such as Enterobacter cloacae, Freund’s citrate and Pseudomonas aeruginosa induce large amounts of enzyme in the presence of suitable β-lactam drugs, but in the absence of such drugs produce only small amounts “Basic” beta-lactamase. As the most commonly used genetics of gram-negative bacteria and clinical most commonly used material is unable to induce β-lactamase E. coli, so the induction of β-lactamase