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磺胺甲氧哒嗪羰甲基亚氨二醋酸(SCIDA)具有良好的肝胆特异性,所得产品元素分析、光谱分析符合预计结果。分子结构中含有磺酰氨基(-SO_2NH-),其疏水端较目前常用肝胆显像剂长,亲脂性强。毒性试验表明使用安全。药盒每瓶含SCIDA21.5mg,氯化亚锡0.2mg。按常规方法标记,标记率96％以上。大白鼠体内分布示肝脏摄取迅速,胆道、肠道内很早即出现放射性。家兔显像显示心影消退快,肝影清晰,胆囊2分钟后即已显现,且持续显影。SCIDA有可能是一种有前途的肝胆显像剂。
Sulfamethoxypyrazine carbonyl methyliminodiacetic acid (SCIDA) has good hepatobiliary specificity, the resulting product elemental analysis, spectral analysis in line with the expected results. Molecular structure contains sulfonamido (-SO_2NH-), the hydrophobic end than the current hepatobiliary imaging agent is often longer, lipophilic and strong. Toxicity tests indicate safe use. Each bottle contains SCIDA 21.5mg, stannous chloride 0.2mg. According to the conventional method of labeling, labeling rate of 96% or more. In vivo distribution of rats showed rapid liver uptake, biliary, intestinal very early radioactive. Rabbit imaging showed rapid regression of heart shadow, liver shadow clear, gallbladder has emerged after 2 minutes, and continued to develop. SCIDA may be a promising hepatobiliary imaging agent.