捷克斯洛伐克布拉格Charles大学眼科的Kreici及Brettschneider通过人胎儿临床观察及动物实验,首次发现盐酸四环素可引起先天性白内障。怀孕的动物或怀孕的妇女肌内注射或口服盐酸四环素均可使子代致病。而哺乳期母亲用四环素时,未断奶的乳儿眼部未见变化。作者指出四环素引起白内障的最危险时期是在妊娠最初 Czechoslovakia Kreici and Brettschneider of the University of Charles in ophthalmology in Prague have found for the first time that tetracycline hydrochloride can cause congenital cataract through clinical observation and animal experiments in human fetuses. Pregnant animals or pregnant women intramuscular injection or oral tetracycline hydrochloride can offspring disease. While lactating mothers with tetracycline, no weaning no changes in the eyes of infants. The authors point out that the most dangerous period of tetracycline-induced cataracts occurs during the first trimester of pregnancy