论文部分内容阅读
以叶绿素降解产物脱镁叶绿酸-a甲酯为起始原料,利用空气氧化反应在12-位上引进甲酰基,再通过氧化、还原、Grignard、Knoevenagel、Cannizzaro和1,3-偶极环加成等经典反应进行官能团转换,并对五元外接E-环实施结构改造,在C(12)-位上分别建立了能与大环色基形成不同共轭程度的酰基、酯基和取代烃基,完成了一系列未见报道的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV,IR,1H NMR及元素分析予以证实,同时也讨论了C(12)-位非甲基化对叶绿素类四吡咯大环分子所形成的各种影响.
Starting from the chlorophyll degradation product pheophorbide-a, the formyl group was introduced into the 12-position by air oxidation followed by oxidation, reduction, Grignard, Knoevenagel, Cannizzaro and 1,3-dipolar ring Functional group transformation with the classical reactions such as addition and addition, and the five-membered external E-ring is structurally modified. Acyl groups, ester groups and substitutions that can form different conjugation degrees with the macrocyclic chromophore are respectively established on the C (12) -position A series of previously reported chlorophyllin chlorin derivatives were synthesized and their chemical structures were confirmed by UV, IR, 1H NMR and elemental analysis. The C (12) Various effects of the alkylation on the chlorophyll tetrapyrrole macrocycle.