化疗已大大改善了急性白血病患儿、特别是急性淋巴细胞白血病(ALL)患儿的预后,约60％患儿获得持续缓解,40％无病长期存活。但20％的长期存活者可有慢性肝病,许多致病因子与其有关,例如药物毒性、白血病浸润、脓毒病和病毒性肝炎。作者检测了23例急性白血病患儿获得持续缓解而停止治疗时,血清和肝组织乙型肝炎病毒(HBV)标记,旨在研究 Chemotherapy has greatly improved the prognosis in children with acute leukemia, especially in patients with acute lymphoblastic leukemia (ALL), with persistent remission in about 60% and long-term disease-free survival in 40%. However, 20% of long-term survivors may have chronic liver disease, many of which are associated with causative agents such as drug toxicity, leukemia infiltration, sepsis and viral hepatitis. The authors tested hepatitis B virus (HBV) markers in serum and liver tissue in 23 children with acute leukemia who received sustained remission and stopped treatment to study