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~(59)Fe、~(60)Co灌胃中毒幼年、成年、老年大鼠,每只一次平均中毒量(MBq):~(59)Fe分别为1.64、1.48、1.04;~(60)Co分别为2.08、2.12、1.81。根据全身和脏器放射性测量结果得出的整体有效滞留分数方程估算大鼠全身和R.M累积剂量。结果表明:骨髓细胞和血淋巴细胞染色体畸变率均比对照组高,且绝大多数剂量点有统计学差异。两核素中毒老年大鼠骨髓细胞无着丝粒畸变率和R.M累积剂量呈线性相关;血淋巴细胞SCE的变化不明显。
~(59)Fe,~(60)Co gavage poisoning in young, adult, and aged rats, the mean poisoning amount (MBq): ~(59)Fe was 1.64, 1.48, 1.04, respectively; ~(60)Co They were 2.08, 2.12, and 1.81, respectively. The systemic and R.M cumulative doses of rats were estimated based on the overall effective retention fraction equation derived from the results of whole body and organ radioactivity measurements. The results showed that the chromosome aberration rate of bone marrow cells and blood lymphocytes was higher than that of the control group, and the majority of dose points were statistically different. There was a linear correlation between the asymmetrized rate of bone marrow cells and cumulative dose of R.M in aged rats with two-nucleotide poisoning; the change of SCE in blood lymphocytes was not obvious.