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ThPOK(T-helper-inducing POZ/Krueppel-like factor)又被称为Zbtb7b、Zfp67、cKrox,隶属于一个很大的转录因子家族——POK家族。ThPOK最初是被认为与Ⅰ型胶原蛋白基因的转录抑制有关,但近年来的研究发现,ThPOK在T细胞分化过程中至关重要,特别是对CD4+T细胞的分化发育起着命运决定的核心作用。该文综述了ThPOK在CD4+T细胞分化过程中的作用特点及其与另外两种重要转录因子GATA3和Runx3的相互作用关系,并在此基础上阐述了ThPOK在其他T细胞,如iNKT细胞、γδT细胞及效应CD8+T细胞中的作用功能。
ThPOK (T-helper-inducing POZ / Krueppel-like factor), also known as Zbtb7b, Zfp67, cKrox, belong to a large family of transcription factors - the POK family. ThPOK was initially thought to be involved in the transcriptional repression of type I collagen genes. However, recent studies have found that ThPOK plays a crucial role in the differentiation of T cells, especially in the development of CD4 + T cells effect. In this review, we summarized the role of ThPOK in the differentiation of CD4 + T cells and its interaction with two other important transcription factors, GATA3 and Runx3. Based on this, we also described ThPOK in other T cells such as iNKT cells, γδT cells and effector CD8 + T cells.