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BACKGROUND:The current methods used for diagnosing hepatocellular carcinoma(HCC)are unsatisfactory.Here,we assessed the serum levels of secreted frizzled related protein 4(s FRP-4)for diagnosing HCC in patients infected with chronic hepatitis B(CHB).METHODS:In 272 patients with CHB enrolled,142 were pa tients with HCC.Thirty-three healthy subjects were recruited as healthy controls.The CHB patients were assigned to a test