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急性和慢性型皮肤移植物抗宿主病(GVHD)兼有许多重要的淋巴细胞介导的皮肤病(变应性接触性皮炎、结核菌素反应、蕈样肉芽肿、皮肤T细胞淋巴瘤、红斑狼疮和扁平苔藓)的临床、病理和免疫学特征,提供了在这些疾病中表皮淋巴细胞相互作用的免疫病理学研究的生物学模型.为什么GVHD中皮肤是主要的靶器官知道得尚不确切.可能的原因是表皮细胞除了表达所有器官都表达的Ⅰ类主要组织相容性复合物(MHC)抗原外,还表达了某些独特的皮肤特异性的非MHC移植抗原.皮肤基底层的表皮干细胞由于渗透脆性或它们所表达的早期分化抗原可能易被损伤.表达Ⅱ类MHC抗原的表皮郎格罕细胞可能是这些病中被
Both acute and chronic GVHD have many important lymphoid-mediated skin diseases (allergic contact dermatitis, tuberculin reaction, mycosis fungoides, cutaneous T-cell lymphoma, erythema Lupus, and lichen planus, providing a biological model of immunopathological studies of epidermal lymphocyte interactions in these diseases. It is not clear why skin is the major target organ in GVHD. A possible reason for this is that in addition to expressing class I major histocompatibility complex (MHC) antigens expressed by all organs, epidermal cells also express certain unique skin-specific non-MHC graft antigens. Epidermal stem cells of the basal layer of the skin Epidermal Langerhans cells expressing class II MHC antigens may be affected by osmotic fragility or the early differentiating antigens they express