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目的:观察小儿咳喘贴对实验动物的局部毒性作用。方法:将小儿咳喘贴药饼敷贴于实验动物去毛皮肤处,观察其皮肤用药的急性毒性、局部刺激和过敏反应,并与正常对照组比较。结果:小儿咳喘贴皮肤用药的急性毒性、局部刺激和过敏反应与正常对照组比较无明显差异。结论:小儿咳喘贴对大鼠皮肤无毒性,无局部刺激性,无致敏性,为临床用药提供了实验依据
Objective: To observe the local toxic effects of cough and asthma in children on experimental animals. METHODS: Pediatric cough and asthma masks were applied to the depilated skin of experimental animals to observe the acute toxicity, local irritation and allergic reactions of the skin agents, and compared with the normal control group. Results: There was no significant difference in acute toxicity, local irritation and anaphylaxis of pediatric cough asthma skin medications compared with the normal control group. Conclusion: Pediatric cough and asthma mask has no toxicity to rat skin, no local irritation, no allergenicity, and provides experimental basis for clinical drug use.