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目的 研究骨肉瘤组织中 p5 3蛋白表达与 PCNA的相关性。方法 应用免疫组化方法测定 33例骨肉瘤中p5 3基因、PCNA的表达 ,均行手术治疗 ,19例获得平均 1年7个月的随访 ,11例发生肺转移 (6例死亡 ) ,3例术后复发。结果 p5 3阳性表达率为 5 7.6 % ,预后良好组 p5 3阳性表达率明显低于预后不良组 ;PCNA阳性表达率为 6 6 .7%。结论 p5 3蛋白阳性表达的骨肉瘤有较强的增殖能力。
Objective To study the correlation between the expression of p53 protein and PCNA in osteosarcoma. Methods Immunohistochemical method was used to detect the expression of p53 and PCNA in 33 cases of osteosarcoma. All cases were followed up by surgery, 19 cases were followed up for an average of 1 year and 7 months, 11 cases were lung metastasis (6 deaths) and 3 cases Recurrence after surgery. Results The positive rate of p5 3 was 57.6%. The positive rate of p5 3 in well-prognosis group was significantly lower than that in poor prognosis group. The positive rate of PCNA was 66.7%. Conclusion The osteosarcoma with p5 3 protein expression has strong proliferative capacity.