人α_1-微球蛋白(α_1-M)是一种重33,000 dalt的低分子量糖蛋白,广泛分布于各种体液中,在肾功能损害患者的血清和尿中,α_1-M升高,因而认为肾脏乃其主要的分解代谢部位。本文报道78例各种肝病成人患者的血清和尿中α_1-M浓度及与肝功能的关系。以60名年龄和性别相配的正常人作对照。另外测定10名正常人,10例失代偿肝硬化和7例肝癌病人尿中α_1-M。标准的α_1-M由低压冻干纯化的α_1-M制备。本文所用的标准α_1-M调整为96mg/L。以1％ Human α 1-microglobulin (α 1-M) is a low-molecular-weight glycoprotein weighing 33,000 dalts and is widely distributed in various body fluids. The α 1-M is elevated in the serum and urine of patients with impaired renal function, The kidney is its main catabolism site. This article reports the serum and urinary levels of α 1-M in 78 adult patients with various liver diseases and their association with liver function. 60 age and gender matched normal controls. In addition, 10 normal subjects, 10 patients with decompensated liver cirrhosis and 7 patients with liver cancer urinary α_1-M. Standard α_1-M was prepared by lyophilization of purified α_1-M. The standard α_1-M used herein was adjusted to 96 mg / L. With 1%