论文部分内容阅读
人精液磷脂酶A2 (PLA2 )由人的前列腺上皮细胞分泌 ,定位于精子头部的前端 ,通过水解甘油磷脂的第 2位酯酰键 ,生成溶血磷脂和脂肪酸在精卵相互作用中发挥作用。近年来发现精液PLA2 与男性不育症有一定关系 ,本文就精液PLA2 的理化性质、作用机理、分子生物学及其与不育症的关系作一综述。
Human sperm phospholipase A2 (PLA2) is secreted by human prostate epithelial cells and localized at the front of the sperm head. Hydrolysis of lysophospholipids and fatty acids plays a role in the sperm-egg interaction by hydrolyzing the 2nd ester bond of glycerophospholipid. In recent years, it has been found that sperm PLA2 and male infertility have a certain relationship, this paper on the physical and chemical properties of semen PLA2, mechanism of action, molecular biology and its relationship with infertility are reviewed.