目的：探讨度洛西汀对酒依赖患者心理依赖及复饮率的影响。方法将142例酒依赖患者按入院先后顺序分为观察组和对照组，每组71例，均给予常规替代、支持治疗，观察组联合口服度洛西汀治疗，观察6周，出院后随访6个月。治疗前后采用汉密顿焦虑量表、汉密顿抑郁量表评定焦虑抑郁状况，随访3个月、6个月统计复饮率。结果治疗第2周末起两组汉密顿焦虑量表、汉密顿抑郁量表评分均较治疗前显著下降（P＜0．01），但观察组各时点评分均显著低于对照组（ P＜0．01）；观察组出院后随访3个月复饮率为12．7％、随访6个月为29．6％，对照组分别为19．7％、54．9％，观察组复饮率显著低于对照组（ P＜0．05或0．01）。结论度洛西汀能有效缓解酒依赖患者的焦虑抑郁情绪，改善心理健康状况，减轻心理依赖程度，有效降低复饮率。“,”Objective To explore the effects of duloxetine on psychological dependence and relapse rate of alcohol dependence (AD) patients .Methods A total of 142 AD patients were assigned to observation and control group of 71 ones each according to admission order ,both groups received routine replacement and supporting therapy ,observation group was plus oral duloxetine for 6 weeks ,and were followed up for 6 months after discharge .Anxiety‐depression conditions were assessed with Hamilton Anxiety Scale (HA‐MA) and Hamilton Depression Scale (HAMD) ,relapse rates counted up at the ends of the 3rd and 6th month follow‐up .Results Since the end of the 2nd week the HAMA and HAMD scores of both groups lowered more significantly compared with pretreatment (P<0 .01) ,those were significantly lower in ob‐servation than in control group at each time‐point (P<0 .01);relapse rates were respectively 12 .7% after 3 month follow‐up and 29 .6% after 6 month in observation and 19 .7% and 54 .9% in control group ,the former significantly lower than the latter (P<0 .05 or 0 .01) .Conclusion Duloxetine could effectively re‐lieve anxious‐depressive emotions of alcohol‐dependent patients ,improve their mental health status ,lessen psychological dependence degree ,and effectively lower relapse rate .