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即使用氯霉素和氨基糖甙类抗生素治疗革兰氏阴性杆菌脑膜炎,病死率仍在40％左右。本文介绍静脉注射 TMP-SMZ 治疗1例克雷白氏肺炎杆菌脑膜炎获得良效,并观察了脑脊液(CSF)TMP-SMZ 杀菌浓度。患者女性,24岁。因头痛、继发性闭经和头颅 X线摄片示蝶鞍扩大而入院。气脑造影证实蝶鞍上部扩大和蝶凹内肿块。作经蝶骨垂体切除术,术中并发蝶鞍隔膜撕裂后 CSF 漏。术后第7天开始鼻腔流
Even with chloramphenicol and aminoglycoside antibiotics for Gram-negative bacilli meningitis, the case fatality rate is still about 40%. This article describes the intravenous injection of TMP-SMZ treatment of one case of Klebsiella pneumoniae meningitis obtained good effect, and observed cerebrospinal fluid (CSF) TMP-SMZ bactericidal concentration. Patient female, 24 years old. Due to headaches, secondary amenorrhea and skull X-ray showed sella enlargement and admission. Air-brain angiography confirmed the enlargement of the upper sella and butterfly concave mass. For transsphenoidal pituitary resection, intraoperative concurrent Sella diaphragm tear after CSF leak. Nasal flow started on the 7th day after surgery