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氟是一种已知可影响骨形成的非激素因子,对骨形成具有双相调节作用;长期小剂量氟可促进骨形成,大剂量可引起骨质疏松或骨硬化。成骨细胞是骨发生和骨形成的重要细胞,具有合成、分泌组成骨基质的胶原和糖蛋白的作用,并通过钙化基质形成骨组织,另外成骨细胞在维持机体内环境的稳
Fluoride is a non-hormonal factor known to affect bone formation and has biphasic modulation of bone formation; long-term, low-dose fluoride promotes bone formation and high doses can cause osteoporosis or osteopetrosis. Osteoblasts are important cells for bone formation and bone formation. They have the function of synthesizing and secreting collagen and glycoproteins that make up the bone matrix and form bone tissue through the calcified matrix. In addition, osteoblasts are stable in maintaining the environment inside the body