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目的 :探讨肾病综合征 (NS)细胞免疫学的变化 ,寻求新的治疗 NS的方法。方法 :选择 5 0例 NS活动期患儿为观察对象 ,随机分为治疗组 30例 ,对照组 2 0例。分别在治疗前、治疗后 1月、治疗后 3月 ,对治疗组进行细胞免疫学检测 ,同时进行两组治疗效果比较。结果 :统计学方差分析得出 CD3,CD4,CD7,CD4/ CD8,NK细胞活性 ,SI,IL-2在治疗后 1月和治疗后 3月分别与治疗前比较有显著性差异 (P<0 .0 5 ) ,治疗后 3月与治疗后 1月比较无显著性差异 (P>0 .0 5 ) ,治疗组与对照组疗效比较 ,经卡方检验χ2 =13.0 2 ,两组之间有非常显著性差异 (P<0 .0 1)。结论 :NS患儿存在细胞免疫功能紊乱 ,表现为 T细胞亚群失衡 ,N K细胞活性 ,SI和 IL-2降低 ,而转移因子具有较强转移特异性细胞免疫的效应 ,调节和改善人体细胞免疫功能 ,增强抗感染能力 ,可做为治疗 NS有效药物
Objective: To investigate the changes of cell immunology in nephrotic syndrome (NS) and seek new ways to treat NS. Methods: Fifty NS children with active stage were selected as observation subjects and randomly divided into treatment group (30 cases) and control group (20 cases). Before treatment, 1 month after treatment and 3 months after treatment, the cellular immunity of the treatment group was tested, and the treatment effect was compared between the two groups. Results: The statistical analysis of variance showed that the activity of CD3, CD4, CD7, CD4 / CD8 and NK cells were significantly different between the two groups .0 5). There was no significant difference between March and March after treatment (P> 0.05). The curative effect between the treatment group and the control group was χ2 = 13.0 2 by chi-square test. There was significant difference between the two groups Very significant difference (P <0.01). CONCLUSIONS: There are cellular immune dysfunctions in children with NS, showing an imbalance of T cell subsets, NK cell activity, decrease of SI and IL-2, while transfer factor has a strong effect of transferring cell-specific immunity to regulate and improve human cellular immunity Function, enhance anti-infective ability, can be used as effective drugs for the treatment of NS