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目的:对收治的50例深部真菌感染患者应用氟康唑治疗进行疗效分析。方法:氟康唑(大扶康)100～200mg/d,静脉1次滴注,疗程3～15天。根据病情,部分病人静脉用药后继以口服胶囊给药,50mg/d。结果:氟康唑治疗深部真菌感染总有效率84%,真菌清除率76%。死亡8例(16%),其中恶性肿瘤者5例。不良反应发生率4%,1例有轻度恶心、呕吐,另1例出现过敏反应,停药后消失。结论:认为凡是严重疾病尤其老年患者发生感染用抗生素治疗1周以上无效应及时想到真菌感染的可能。应早期给予尿、粪、痰真菌镜检及培养。氟康唑为新型三唑类抗真菌药物,具有疗效好、副作用轻、使用安全的特点,值得临床上广泛应用。
Objective: To treat 50 patients with deep fungal infection treated with fluconazole for efficacy analysis. Methods: Fluconazole (Tai Fukang) 100 ~ 200mg / d, intravenous infusion, the course of 3 to 15 days. According to the disease, some patients intravenous medication followed by oral capsule administration, 50mg / d. Results: The total effective rate of fluconazole in treating deep fungal infection was 84% and the fungal clearance rate was 76%. 8 cases died (16%), of which 5 cases of malignant tumors. The incidence of adverse reactions 4%, 1 case of mild nausea and vomiting, another case of allergic reactions, disappeared after stopping. Conclusion: It is considered that any serious disease, especially in elderly patients, should be treated with antibiotics for more than one week without any effect, and think of the possibility of fungal infection in time. Early urine, feces, sputum fungi microscopy and culture. Fluconazole is a new triazole antifungal drug with good curative effect, light side effects and safe use, which is worth widely used in clinic.