论文部分内容阅读
为探讨基质金属蛋白酶MMP9及其抑制剂TIMP1在喉癌中表达的意义，我们采用免疫组化法对它们在36例喉癌中的表达进行研究，结果显示：MMP9及TIMP1的阳性表达率，淋巴结转移组明显高于无淋巴结转移组，T3～T4期高于T1～T2期。研究结果表明，TIMP1增高的程度不足以抑制MMP9的活性，MMP9与喉鳞癌的浸润及转移密切相关，在只粘膜癌变癌细胞突破基底膜呈浸润性生长中起到重要的作用。
To investigate the significance of MMP9 and its inhibitor TIMP1 expression in laryngeal carcinoma, we used immunohistochemistry to study the expression of MMP9 and TIMP1 in 36 cases of laryngeal carcinoma. The results showed that the positive rate of MMP9 and TIMP1, lymph node Metastasis group was significantly higher than without lymph node metastasis, T3 ~ T4 period is higher than T1 ~ T2 period. The results show that the increased level of TIMP1 is not enough to inhibit the activity of MMP9. MMP9 is closely related to the invasion and metastasis of laryngeal squamous cell carcinoma, which plays an important role in invasive carcinoma of the mucosa cancerous cells.