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心肌重构是心肌对多种刺激因素所产生的适应性变化。在重构过程中,心肌细胞内发生一系列信号转导方面的改变,钙调神经磷酸酶介导的信号转导是胞外信号传递至核内的关键环节,现将阐述钙调神经磷酸酶在细胞重构、组织重构、电重构、功能重构方面的作用,及钙调神经磷酸酶的几种抑制剂,并介绍钙调神经磷酸酶通路与其他信号转导通路间联系。
Cardiac remodeling is a cardiomyotropic response to a variety of stimuli. In the process of remodeling, a series of signal transduction changes occur in cardiomyocytes. Calcineurin-mediated signal transduction is the key link of extracellular signal transduction to the nucleus. We will now describe the role of calcineurin In the role of cell remodeling, tissue remodeling, electrical remodeling, functional remodeling and several inhibitors of calcineurin, and describes the relationship between the calcineurin pathway and other signal transduction pathways.